BNSF, the train operator, said no injuries were reported to its crew. The railroad said it was working with authorities to investigate and clean up the site.
State Patrol spokesman Gabriel Moltrer said the truck driver suffered “fatal injuries.” The Pueblo County Coroner’s office has not released the driver’s name.
A stretch of the interstate, which runs north-south through Colorado via Denver, remained closed in both directions Monday. The section of highway carries about 40,000 vehicles daily.
“This will be an extended closure,” the Colorado Department of Transportation said in a bulletin for drivers.
The National Transportation Safety Board launched an investigation into the derailment, with a team expected to arrive at the scene Monday. Sarah Taylor Sulick, an NTSB spokeswoman, said the investigation also will examine the bridge and its maintenance.
The bridge is owned by BNSF. While data on road bridges is released by federal officials, inspection reports for bridges owned by railroads are not routinely released to the public.
Transportation Secretary Pete Buttigieg said Sunday he talked to Colorado Gov. Jared Polis (D) about the derailment and that officials from his department were on their way to the scene.
BNSF has had 177 derailments this year, according to the latest Federal Railroad Administration data.
Lawmakers have been weighing changes to rail safety laws after a February derailment in East Palestine, Ohio, which involved the release of hazardous chemicals. A Senate committee approved a bill in May, but it has not come up for a vote on the Senate floor.